RYBP and Cbx7 Define Specific Biological Functions of Polycomb Complexes in Mouse Embryonic Stem Cells
The Polycomb repressive complex 1 (PRC1) is required for decisions of stem cell fate.In mouse embryonic stem cells (ESCs), two major variations of PRC1 complex, defined by the mutually exclusive presence of Cbx7 huge-anal or RYBP, have been identified.Here, we show that although the genomic localization of the Cbx7- and RYBP-containing PRC1 complex